Characterizing Vaccines with the Light Scattering Toolkit

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Overview

This paper includes a brief introduction to light scattering (LS) instruments and techniques, and how they are coupled with fractionation techniques. For several classes of vaccines – including subunit vaccines, mRNA-LNPs, polysaccharide conjugates, and plain old viruses – case studies demonstrate the utility and breadth of analyses using the light scattering toolkit.

These include measuring size distributions, characterizing protein-protein binding, and quantifying glycan content in glycoproteins or nucleic acid cargo in nanocarriers. Multiple ways to detect aggregation and other measures of stability are also described.

Key Objectives：

The basic types of analytical LS and the information they provide
How LS may be used to evaluate vaccine stability and particle concentration
The uses of LS in developing and manufacturing viral and non-viral gene vector vaccines
The benefits of LS for characterizing glycosylation and viral glycoprotein-antibody binding

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