Emerging drug discovery strategies for targeted protein degradation

Emerging drug discovery strategies for targeted protein degradation

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Overview

Targeted protein degradation can be used to achieve efficacy in various disease contexts where other therapies fail. PROTACs® are unique, high-molecular-weight compounds that facilitate the labeling of a target protein, marking it for removal by cellular degradation machinery. These molecules bring two proteins together, and action dependent on the formation of a three-part complex introduces challenges during drug discovery and development.

Learn how to identify PROTAC candidates using DNA-encoded libraries and explore specialized screening and analytical techniques for target validation, compound optimization, mechanistic studies, and in vivo testing.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Key Objectives:

PROTACs® are an emerging treatment modality with promise for treating a range of diseases.
DNA-encoded libraries are well suited for the screening and identification of PROTACs.
PROTACs are high molecular weight compounds with unique mechanisms of action that require careful preparation and analysis.

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