Next Level Purification Efficiency for Small Molecule Targets and Beyond

Next Level Purification Efficiency for Small Molecule Targets and Beyond

Brought to you by Waters Corporation

Overview

HPLC purification is powerful and its purpose practical:

Recover the target compound
Obtain desired target purity and yield
Complete the purification in the least amount of time

“Sticky” compounds seemingly hang up in the preparative column and are difficult to effectively detect and collect. When this occurs, prep separations degrade, and the target’s purification success is at risk. In particular, metal-sensitive targets can adsorb to positively charged metal surfaces in the flow path and column. These non-specific adsorbers (NSAs) behave unpredictably and can lead to sample loss, compromised purity or low throughput. Learn how to overcome these issues in LC purifications and improve productivity with a new OBD preparative column technology that is inert to analytes that may be prone to non-specific binding.

Key Objectives:

What types of compounds can be NSAs
What are the chromatographic issues NSAs exhibit and the impact they have on compound purification
How to mitigate NSA challenges with inert preparative columns
How to safeguard your purifications even when isolating compounds with unknown structures which may be non-specific adsorbers
How improving sensitivity can significantly improve outcomes from batch library purifications or for other samples where first-time injection success is paramount to retrieve even low-level targets

Brought to you by:

This content was created by Waters Corporation, without editorial input from the C&EN Media Group. For more information on C&EN's custom products, visit our C&EN Media Kit.

Please complete the form to register for the webinar.

Forwarded this link? Clear the form

Email Address*

Salutation*

First Name*

Last Name*

Company*

Job Title

Address 1*

City*

State*

Zip / Post Code*

Country/Territory/Area*

Business Phone*

I am interested in a Waters representative to reach out to me.

I would like to receive C&EN’s weekly newsletter with the latest in chemistry news

I would like to receive more information on products and services from the American Chemical Society

address2

*By submitting this form, you agree to receive more information on related products and services from the American Chemical Society (ACS Publications) and its sponsor via email. ACS takes your privacy seriously. For more information, please see the ACS Privacy Policy.