Effective LC Workflow Strategies in Discovery Chemistry Research

Effective LC Workflow Strategies in Discovery Chemistry Research

Brought to you by Waters Corporation

Overview

In discovery chemistry, synthetic chemists spend significant effort designing and synthesizing novel compounds. Moving from raw reaction to pure compound requires not just chemistry, but the right analytical tools.

This webinar explores how liquid chromatography (LC), both analytical and preparative, answers key questions in the synthesis workflow: Has the reaction completed? Is the desired compound present? How pure is it? Can it be successfully isolated?

Chris Collins and Kathy Lawrence will guide attendees through effective LC strategies for analyzing and isolating molecular targets, showing how UPLC aids reaction monitoring and preparative LC can be scaled efficiently. The session will also cover sorbent selection, column attributes, and method considerations to minimize sample loss and optimize performance.

Key Objectives:

Best practices for scaling to preparative LC
The impact of column chemistry and sorbent attributes on isolation success
Tips to reduce sample loss and increase purification efficiency
How to improve lab-scale HPLC workflows in discovery research
How to plan for and deal with problematic targets in advance of scale-up

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