The ABC of ADCs: Fundamentals of Technical, Regulatory, and Clinical Insights

The ABC of ADCs: Fundamentals of Technical, Regulatory, and Clinical Insights

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Overview

Designing effective ADCs is a complex task, requiring the precise coordination of antigens, antibodies, linkers, and payloads. The challenge lies in targeting tumor cells while avoiding damage to normal tissues, ensuring the therapeutic payload is delivered accurately and efficiently.

This white paper, authored by Dr. Kishore Hotha, provides a comprehensive overview of ADCs, covering the fundamental technical aspects, regulatory challenges, and clinical insights. It includes detailed discussions on antibody selection, linker-payload compatibility, and the latest advancements in ADC technology. Readers will also gain insights into recent ADC approvals and the status of late-stage clinical trials for cancer-specific ADCs

Key Objectives:

Understand the fundamental components of ADCs, including antigens, antibodies, linkers, and payloads.
Explore the technical challenges in designing ADCs for targeted cancer therapy.
Gain insights into the regulatory landscape governing ADC development and approval.
Learn about the current landscape of ADCs in late-stage clinical trials.

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