Inconsistent sampling can lead to incorrect conclusions about reaction progress, yield, and quality. Therefore, accurate and reproducible sampling is crucial, especially when scaling up chemical processes.

This application note is based on research carried out by a team of scientists at Pfizer. They evaluated the sampling reproducibility of the ReactALL™ system with SmartCap™ technology. Using diphenyl ether in acetonitrile and a mixture of diphenyl ether and sodium tosylate in toluene, the results demonstrate consistent and reliable sampling performance, comparable to manual sampling. Furthermore, the results were achieved with minimal variability in both homogeneous and heterogeneous mixtures.