C&EN App Note
Ensuring reproducibility in process chemistry with automated sampling
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Overview

Inconsistent sampling can lead to incorrect conclusions about reaction progress, yield, and quality. Therefore, accurate and reproducible sampling is crucial, especially when scaling up chemical processes.

This application note is based on research carried out by a team of scientists at Pfizer. They evaluated the sampling reproducibility of the ReactALL™ system with SmartCap™ technology. Using diphenyl ether in acetonitrile and a mixture of diphenyl ether and sodium tosylate in toluene, the results demonstrate consistent and reliable sampling performance, comparable to manual sampling. Furthermore, the results were achieved with minimal variability in both homogeneous and heterogeneous mixtures.

Key Objectives
  • Understand the benefits of automated sampling in improving precision and minimizing errors. 
  • Learn how ReactALL’s SmartCap technology ensures consistent and representative sampling for both homogeneous and heterogeneous reactions. 
  • Explore how automated quenching and dilution capabilities streamline workflows and ensure reliable sample analysis.

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