Amorphous materials, known for improving solubility and dissolution rates, face stability challenges, losing their beneficial properties. Stabilizing these materials in a polymer matrix through amorphous solid dispersions helps retain their advantages. By embedding active ingredients in polymers, the stability and solubility are enhanced, with formulation optimization achieved by adjusting solvents, drug loads, and temperature profiles. Polymers also exhibit different thermal behaviors, such as LCST (Lower Critical Solution Temperature), which are important for developing controlled drug delivery systems. Automated systems, such as the Crystal16® , enhance efficiency in drug formulation by determining solubility curves and dissolution rates through transmissivity measurements, which also help identify key processes like micelle formation.