Cell Culture Media Analysis – Monitor Daily Nutrient Consumption to Optimize Media Development

DATE

March 19, 2026

TIME

8:00 a.m. PDT, 11:00 a.m. EDT, 16:00 GMT, 17:00 CET - Duration: 60 Minutes

Overview

Subtle shifts in amino acid availability—whether depletion or excess—can alter feed effectiveness, drive toxic metabolite formation, and impact overall upstream process performance. Yet in many development workflows, amino acid data is generated too late to guide meaningful decisions.

For decades, upstream teams have relied on centralized mass spectrometry workflows to analyze cell culture media. While analytically powerful, these approaches require specialized expertise and long turnaround times, limiting access to timely nutrient insight during active experiments.

This webinar addresses the critical need for real-time, at-line cell culture media analysis to support media optimization and feed strategy development. Jérémie Barbau will discuss how rapid, quantitative amino acid profiling enables scientists to better understand nutrient dynamics, reduce uncertainty, and make informed adjustments while experiments are still underway. Supported by recent PATsmart™ REBEL® XT validation and application studies, the session illustrates how at-line analysis provides reliable insight that improves upstream process understanding and decision-making.

Key Learning Objectives:

Why reliance on centralized mass spectrometry often delays amino acid insight beyond the point where feed strategy adjustments can be effective.
How at-line amino acid analysis delivers reliable, quantitative media data without requiring specialized analytical expertise, enabling more frequent and practical monitoring.
How timely access to comprehensive amino acid profiles changes how scientists design, adjust, and justify media and feed strategies during upstream development.

Who Should Attend:

Upstream Process Development Scientists
Cell Culture and Media Development Scientists
Bioprocess Engineers (Process Development / MSAT)
Process Analytical Technology (PAT) and Bioprocess Analytics Specialists

Brought to you by:

Speakers

Jérémie Barbau
Senior Field Application Scientist,
Repligen

Melissa O'Meara
Forensic Science Consultant,
C&EN Media Group

Registration

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The PATsmart™ REBEL® XT System delivers the next level of at-line cell culture media analysis and results for over 20 key components in approximately 15 minutes for deeper process optimization and understanding. Would you like a Repligen analytics specialist to contact you to learn more about the REBEL XT System?*

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