C&EN White Paper
High-resolution mass spectrometry: a powerful technology in drug discovery and process development
Brought to you by Olon S.P.A

In the last decade, high-resolution mass spectrometry (HRMS) has emerged as a powerful technique in many fields of biological studies, pharmaceutical and nutraceutical research and environmental analysis.

Thanks to the high resolution and accuracy in results, targeted and untargeted analysis and structural information obtained by MS in tandem analysis, the QTOF-MS instrument has been widely exploited for comprehensive drug screening in biological samples.

Olon uses a well-established technological platform to produce peptides via a recombinant approach that involves strain design, construction and improvement, as well as fermentation and downstream process design and optimization for the isolation and purification of peptides as active pharmaceutical ingredients (APIs).

The process, and particularly the purification step, must ensure not only consistent quality through all batches, but also the safety and efficacy of the final product. To this end, this whitepaper shows how a HRMS method can be used to identify and characterize unknown impurities in samples of recombinant peptides.

Key Objectives:
  • Learn how to apply high resolution mass spectrometry in drug R&D and process development to ensure consistent product quality, efficacy and safety.
  • Discover how QTOF MS instruments also can be exploited for the analysis of recombinant peptides and identification of impurities.
  • See how an LC-QTOF-ESI method can routinely provide both high resolution and accurate mass results to help identify unknown impurities, and fragmentation spectra supporting the characterization of small molecules formed during synthesis.

Brought to you by:
Olon S.P.A
This content was created by Olon S.P.A, without editorial input from the C&EN Media Group. For more information on C&EN's custom products, visit our C&EN Media Kit.
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