C&EN White papers | How a Next Generation Affinity-Based Assay Complements Mass Spectrometry

How a Next Generation Affinity-Based Assay Complements Mass Spectrometry

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Overview

This white paper explores how the Proximity Extension Assay (PEA^TM), a next generation affinity-based method, complements mass spectrometry (MS) proteomic research. PEA^TMand MS have unique strengths: PEA^TM excels in detecting low-abundance proteins with high specificity and sensitivity, maintaining throughput across all sample types, including plasma. Liquid-chromatography MS (LC-MS) provides unbiased protein coverage and detects isoforms and post-translational modifications.

By combining these technologies, researchers can expand proteome coverage and streamline the validation of protein signatures. This white paper provides a detailed comparison of PEA^TM and LC-MS with examples of published research where this combination has proven successful.

Key Objectives:

Learn what is PEA^TM and how it works.
Delve into a detailed technical comparison between PEA^TMand LC-MS.
Review summaries of key publications demonstrating the complementarity of PEA^TM and LC-MS.

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