C&EN White Paper
Using Synthesis and Route Design Technology to Approach API Complexity
Brought to you by Lonza Small Molecules

The increasing complexity of small molecules entering the drug development pipeline is a real challenge, not least because the synthetic routes to make them are often long. This adds to the issues facing process chemists as they look for a cost-effective and high-yielding synthesis for scale-up and commercialisation. Supply chain complexity is a knock-on concern that can also add to costs. Taken together, these issues mean there is a significant risk that development timelines may not be met.

As a result, computer-aided synthesis design technologies (CDSTs) have been developed to assist in finding the most effective synthetic route for a given molecule. In this white paper, we look at how our two companies have worked together to develop a retrosynthesis process that meets the needs of process chemists in Lonza’s Preclinical Route Design group. It combines Elsevier’s Reaxys technology with Lonza’s real-world experience and supply chain insights. The result is a route scouting service that is already helping to mitigate API complexity and accelerate small molecule drugs’ route to market.

Key Objectives:
  • API synthesis
  • Computer-aided synthesis design technologies
  • Pharmaceutical process development
  • Synthetic route design
  • Retrosynthetic analysis

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This content was created by Lonza Small Molecules, without editorial input from the C&EN Media Group. For more information on C&EN's custom products, visit our C&EN Media Kit.
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