Evaluating drug-drug interactions – a framework from lab to clinic

DATE

November 12, 2025

TIME

11:00 EST / 8:00 AM PST/ 16:00 GMT (UK) / 17:00 CET- Duration: 60 Minutes

Overview

Evaluating drug interactions – a framework from lab to clinic

Despite decades of research, drug–drug interactions continue to undermine treatment outcomes. They affect more than 10% of patients in some populations and account for up to 30% of hospitalisations linked to adverse drug reactions.

In this webinar, Professor Tore Stage will use isoxazolyl penicillins as a case study to demonstrate an integrated framework for evaluating drug-drug interactions, showing how dicloxacillin and flucloxacillin act as metabolic inducers with clinically significant consequences.

To uncover these effects, the project combined complementary methods: hepatocyte cultures in 2D and 3D formats with qPCR and LC–MS/MS analysis, pharmacokinetic studies in healthy volunteers using a probe–drug cocktail design, and register-based studies to assess real-world outcomes. Together, these approaches form a transferable model for evaluating drug-drug interactions from bench to clinic.

Key Learning Objectives:

Recognize the clinical impact of drug–drug interactions and their role in adverse outcomes.
Understand how complementary methods integrate to evaluate drug-drug interactions.
Apply insights from isoxazolyl penicillins as a transferable case study.

Who Should Attend:

Scientists in drug metabolism and pharmacokinetics.
Clinical pharmacologists and healthcare professionals.
Pharmaceutical R&D professionals involved in drug-drug interaction studies.

Brought to you by:

Speakers

Tore B Stage
Head of Research,
Professor of Clinical Pharmacology,
Pharmacy and Environmental Medicine,
The University of Southern Denmark

Dr. Joe Lackey
Technical Manager,
LGC Standards

Kelly McSweeney
Contributing Editor,
ACS Media Group

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