T3P – A Green Solution for Peptide Coupling and Water Removal Reactions

DATE

December 4, 2025

TIME

8:00 a.m. PST, 11:00 a.m. EST, 16:00 GMT, 17:00 CET - Duration: 60 Minutes

Overview

Curia's T3P or propanephosphonic acid anhydride, is an exceptional green reagent for use in condensation reactions and has attracted the attention of almost all innovative pharmaceutical companies worldwide during the past decade. Many applications for T3P use are in amidations and peptide coupling reactions — both LPPS (liquid-phase peptide synthesis) and SPPS (solid-phase peptide synthesis).

However, the reagent may readily be used for various other functional group transformation reactions including nitrile formation, alcohol oxidation (Swern-type oxidation), ester formation, heterocycle formation and many more.

Key Learning Objectives:

A green alternative to commonly used coupling agents
Process advantages of T3P
T3P advantages as greener reagent

Who Should Attend:

R&D of API manufacturers
Sourcing managers
Peptide developers
Small molecule developers
New product developers

Brought to you by:

Speakers

Dr. Peter Talbiersky
Director of Fine Chemicals,
Curia Global, Inc

Melissa O'Meara
Forensic Science Consultant,
C&EN Media Group

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