Harnessing Chemistry for Scalable Manufacture of Lipids Used in mRNA Delivery

Harnessing Chemistry for Scalable Manufacture of Lipids

Used in mRNA Delivery

Brought to you by Curia

Overview

Lipid nanoparticles (LNPs) were a critical element in the rapid development of mRNA vaccines during the COVID-19 pandemic, but their effectiveness will extend to many other diseases. However, to produce LNP therapeutics at scales required for global rollouts, the chemistry of lipid synthesis must be carefully optimized.

This white paper will describe the various challenges and solutions involved in lipid synthesis and purification for successful LNP-based therapeutics.

Key Objectives:

How the different components of a LNP contribute to its function and stability.
The critical role of minimizing impurities during lipid synthesis.
Preferred purification methods for large-scale lipid synthesis.
The future of LNP-based mRNA delivery, including developments that enable more precise tissue- and cell type-targeting and improve LNP stability.

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