Unlocking ADC Breakthroughs Through Payload-Linker Chemistry Innovations

DATE

September 3, 2025

TIME

8:00 a.m. PDT, 11:00 a.m. EDT, 16:00 BST, 17:00 CEST

Overview

Antibody-drug conjugates (ADCs) have emerged as one of the most promising modalities in oncology, and the chemistry behind the payload-linker design plays a pivotal role in efficacy, safety, and manufacturability. In this webinar, Jack Gengcheng Yang, a Senior Director and a seasoned payload-linker expert from WuXi XDC will share how cutting-edge innovations in payload-linker chemistry are driving the next wave of ADC breakthroughs.

The session will explore cleavable and non-cleavable linker technologies, processes for high-quality and cost-effective manufacturing of payload-linkers, new classes of payload-linkers under development, strategies for improving DAR, stability, solubility, and bystander effects with innovative payload-linkers and our proprietary payload linker technologies. Attendees will also learn how WuXi XDC’s one-stop CRDMO platform supports partners from discovery through GMP manufacturing and IND filing. Case studies will highlight how integrated execution accelerates timelines, lowers cost, and de-risks ADC development.

Key Learning Objectives:

New trends in linker and payload design to enable next-gen ADCs
Chemistry innovations driving improved stability and solubility of ADCs, including new linker structures of WuXi XDC and partners that are free to use for ADC development clients.
How WuXi XDC helps global partners move from concept to IND filing, and clinic success.

Who Should Attend:

ADCs/Bioconjugates Developers
Process & Analytical Chemists
Formulation Scientists
Translational / Preclinical Researchers

Brought to you by:

Speakers

Jack Gengcheng Yang
Senior Director, Payload-linker Chemistry
WuXi XDC

Kelly McSweeney
Contributing Editor
C&EN Media Group

Registration

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