CQA Assessment of GLP-1 Agonist with SEC-MALS

DATE

October 15, 2025

TIME

8:00 a.m. PDT, 11:00 a.m. EDT, 16:00 BST, 17:00 CEST - Duration: 60 Minutes

Overview

Characterizing GLP-1 receptor agonists (GLP-1RAs), now central to diabetes and weight management therapies, demands precise and reliable analytical methods across development, manufacturing, and quality control. This webinar explores how light scattering techniques—including dynamic light scattering (DLS) and multi-angle light scattering (MALS)—enable detailed assessment of critical quality attributes (CQAs). With a particular focus on MALS coupled to size-exclusion chromatography (SEC-MALS) under native and denaturing conditions, attendees will learn how these approaches provide robust, quantitative insights into molar mass, size, aggregation, and oligomeric state, as well as their impact on colloidal stability.

Case studies will showcase the characterization of GLP-1 analogs—including liraglutide, semaglutide, and related peptides—highlighting applications such as aggregation screening, impurity profiling, and stability analysis. The session will also discuss how the latest iteration of Empower™ Chromatography Data System integrates advanced detectors for orthogonal characterization in QC workflows, delivering secure, compliant data handling to support product integrity and regulatory readiness.

Key Learning Objectives:

Understanding GLP-1a: Learn about the biological functions and therapeutic importance of GLP-1 analogs in treating obesity and type-II diabetes.
Analytical Techniques: Gain knowledge on advanced light scattering for characterizing peptide drugs in the detection of aggregates, oligomeric states and peak heterogeneity.
Case Studies: Explore real-world applications of light scattering techniques in assessing the quality and stability of GLP-1a drugs.
Transfer to your lab: Learn what columns and conditions are required for ideal results and conditions for your own studies

Who Should Attend:

Peptide Formulation Scientists and Analytical Chemists focused on peptide-based therapeutics, such as GLP-1, to evaluate stability and aggregation.
QC Scientists in peptide drug discovery and development, specializing in evaluating multivalent peptide interactions in GXP Labs
Lab Managers looking to understand state-of-the-art instruments that enhance analytical capabilities.

Brought to you by:

Speakers

Udayabagya (Bud) Halim
Sr. Market Analyst,
Waters | Wyatt Technology

Kelly McSweeney
Contributing Editor,
C&EN Media Group

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