Advanced HILIC Workflows for GLP-1 Agonist Impurity Profiling

DATE

FIRST SESSION: August 14, 2025

SECOND SESSION: October 7, 2025

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TIME

FIRST SESSION: August 14, 2025

8:00 A.M. PDT, 11:00 A.M. EDT, 16:00 BST, 17:00 CEST

Duration: 60 Minutes

SECOND SESSION: October 7, 2025

12:30 P.M. IST, 9:00 A.M. CEST, 4:00 P.M. JST

Duration 60 Minutes

Overview

GLP-1 receptor agonists like Semaglutide and Tirzepatide are complex therapeutic peptides used in treating type 2 diabetes and obesity. Their structural complexity and formulation with diverse excipients pose significant analytical challenges. This webinar will explore impurity profiling and excipient analysis using orthogonal HILIC-UV/MS and HILIC-ELSD workflows.

Attendees will gain insights into mitigating nonspecific adsorption issues and improving method robustness using low-adsorption LC flow paths. The session will also highlight how these workflows complement traditional methods and support regulatory compliance through Analytical Quality by Design (AQbD) principles.

Key Learning Objectives:

Understand the structural and analytical challenges of GLP-1 receptor agonists.
Learn how HILIC-UV/MS and HILIC-ELSD workflows enhance impurity profiling.
Discover strategies to reduce nonspecific adsorption and improve recovery.

Who Should Attend:

Laboratory Managers
Chromatographers
Biopharmaceutical Scientists
Analytical Chemists

Brought to you by:

Speaker

Amanda Guiraldelli Mahr, Ph.D.
Senior Scientist, Proteins Chemistry and Separation,
RIC Group, Belgium

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