Variable Pathlength Spectroscopy for Dilution-Free Concentration Measurement in GMP Environments

February 7, 2024
8:00 a.m. PST / 11:00 a.m. EST / 16:00 GMT / 17:00 CET - Duration: 60 Minutes


Traditional UV/Vis spectroscopy uses fixed pathlengths to measure different analytes, such as nucleic acids, proteins, and cells from biological samples. These samples are often limited in volume or highly concentrated, which presents various challenges.  

The CTech™ SoloVPE® System uses patented variable pathlength technology (VPT) to accurately measure the targeted concentration of various analytes in less than 2 minutes. The system can measure concentrations without being dependent on sample volume or sample concentration, removing any dilution requirements. 

In this webinar, we will review VPT and how it can be used in various applications from protein to nucleic acid therapeutics. We will share real-world case studies demonstrating how companies have integrated the SoloVPE System into their manufacturing workflow for release and in-process testing.  

Key Learning Objectives:
  • The science of variable pathlength spectroscopy and why variable pathlength provides better accuracy than traditional fixed pathlength methods
  • Overview of the SoloVPE System and the benefits:  
  • No sample dilutions
  • Guaranteed linear results 
  • No baseline correction
  • Testing of low and very high concentration samples from 0.01 mg/mL up to 300mg/mL (MAbs) 
  • Implementing in the analytics/QC lab or in the production suite for at-line testing (IPT)  
  • Review SoloVPE implementation in multiple applications - quantitate proteins, nucleic acids and excipient analysis, such as polysorbate and free sulfhydryl concentrations
Who Should Attend:
  • Process Development Scientist 
  • Analytical Development Scientist  
  • Quality Control, Quality Assurance Scientist
  • Manufacturing Science and Technology (MSAT) Scientist 

Brought to you by:
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Joe Ferraiolo
Director, Bioanalytics Applications,
Catherine Dold
Health & Environment Writer,
C&EN Media Group


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