Variable Pathlength Spectroscopy for Dilution-Free Concentration Measurement in GMP Environments

DATE

February 7, 2024

TIME

8:00 a.m. PST / 11:00 a.m. EST / 16:00 GMT / 17:00 CET - Duration: 60 Minutes

Overview

Traditional UV/Vis spectroscopy uses fixed pathlengths to measure different analytes, such as nucleic acids, proteins, and cells from biological samples. These samples are often limited in volume or highly concentrated, which presents various challenges.

The CTech™ SoloVPE® System uses patented variable pathlength technology (VPT) to accurately measure the targeted concentration of various analytes in less than 2 minutes. The system can measure concentrations without being dependent on sample volume or sample concentration, removing any dilution requirements.

In this webinar, we will review VPT and how it can be used in various applications from protein to nucleic acid therapeutics. We will share real-world case studies demonstrating how companies have integrated the SoloVPE System into their manufacturing workflow for release and in-process testing.

Key Learning Objectives:

The science of variable pathlength spectroscopy and why variable pathlength provides better accuracy than traditional fixed pathlength methods
Overview of the SoloVPE System and the benefits:
No sample dilutions
Guaranteed linear results
No baseline correction
Testing of low and very high concentration samples from 0.01 mg/mL up to 300mg/mL (MAbs)
Implementing in the analytics/QC lab or in the production suite for at-line testing (IPT)
Review SoloVPE implementation in multiple applications - quantitate proteins, nucleic acids and excipient analysis, such as polysorbate and free sulfhydryl concentrations

Who Should Attend:

Process Development Scientist
Analytical Development Scientist
Quality Control, Quality Assurance Scientist
Manufacturing Science and Technology (MSAT) Scientist

Brought to you by:

Speakers

Joe Ferraiolo
Director, Bioanalytics Applications,
Repligen

Catherine Dold
Health & Environment Writer,
C&EN Media Group

Registration

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