Advancements in Cross-Coupling Catalysis with MPhos, A Novel Tunable Ligand

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DURATION: 60 MINUTES

Overview

Transition metal catalyzed cross-coupling reactions are one of the most important and widely used reactions in modern organic synthesis. In this presentation, you will learn about a newly developed class of phosphine ligands targeting a relatively underexplored type of cross-coupling reaction.

MPhos is a novel class of ferrocene-based unsymmetrical ligands. Along with their corresponding PdCl2 pre-catalysts, these ligands are employed for a variety of Csp2-Csp3 couplings reactions such as Murahashi-Feringa, Kumada-Corriu, Negishi and Suzuki-Miyaura. Various substrates include “drug-like” molecules to demonstrate its potential applications in API synthesis. The details of the study will be discussed in the presentation.

Key Learning Objectives:

Difficulties in Csp2-Csp3 Couplings
Benefits of MPhos ligands and precatalysts

Who Should Attend:

Synthetic chemists interested in learning about a new class of cross-coupling catalysts
Medicinal chemists seeking additional ligands and catalysts for high-throughput screening

Brought to you by:

Speakers

Thomas Colacot
R&D Fellow and Director of Global Technology Innovation, Life Science Business,
MilliporeSigma

Ann Thayer
Contributing Editor,
C&EN Media Group

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